The Global Cardiovascular Innovation Center (GCIC) is a cardiovascular research and product development consortium made possible through a grant from the State of Ohio’s Third Frontier Project. Founded in 2007, GCIC is the first Wright Mega-Center of Innovation under this program. GCIC is led by the Cleveland Clinic and comprised of the following five leading Ohio institutions: Case Western Reserve University, The Ohio State University, The University of Cincinnati, The University of Toledo and University Hospitals of Cleveland. These academic healthcare facilities contribute outstanding cardiovascular research excellence and clinical capabilities to GCIC to promote the commercialization of new products and the creation of new companies in the State of Ohio. Estimated at more than $420 billion, cardiovascular medicine is the largest healthcare market opportunity in the US. The cardiovascular disease burden poses clear medical, scientific, and commercial challenges. GCIC is building cross-industry partnerships to facilitate the development and adoption of new cardiovascular technologies geared towards improving patient care. Cardiovascular research and commercialization – along with millions of patients – will benefit from the progress made through companies affiliated with GCIC. GCIC is focused on the formation, attraction, expansion and retention of cardiovascular companies to create jobs and facilitate economic development in the State of Ohio.